From Neural Signatures to Classroom Strategies: A Theoretical Model for Educational Intervention in Children with Autism Spectrum Disorder Based on Neuroimaging
DOI:
https://doi.org/10.71222/qvga5f21Keywords:
autism spectrum disorder, neuroimaging, educational intervention, neuroeducationAbstract
Current educational intervention measures often lack a direct connection to the underlying neural mechanisms of ASD. To address this issue, the research, building upon the team's Connectome Computation System (CCS), critically synthesizes existing literature on ASD neurobiology and evidence-based educational strategies to construct a three-tier "neuro-educational" transformation framework. This theoretical model links the neural signatures identified by CCS with the cognitive-behavioral profiles of children with autism, thereby deriving targeted educational principles and actionable classroom strategies. The conclusion asserts that this structured model provides a crucial, scientifically-grounded pathway for translating individual neurocognitive assessments into personalized educational interventions, thereby enhancing the precision, efficacy, and theoretical coherence of support measures for children with ASD in classroom settings.
References
1. M. L. Bauman, and T. L. Kemper, "Neuroanatomic observations of the brain in autism: a review and future directions," International journal of developmental neuroscience, vol. 23, no. 2-3, pp. 183-187, 2005. doi: 10.1016/j.ijdevneu.2004.09.006
2. R. A. Bethlehem, J. Seidlitz, S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, and H. L. Schaare, "Brain charts for the human lifespan," Nature, vol. 604, no. 7906, pp. 525-533, 2022.
3. J. Blom, C. Ruggerini, F. Caroli, C. Ferreri, A. Masi, V. Rivi, and C. Arletti, "Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder," Frontiers in Psychiatry, vol. 16, p. 1608033, 2025.
4. A. Calderwood, V. Qiu, K. I. Gero, and L. B. Chilton, "How novelists use generative language models: An exploratory user study," In HAI-GEN+ user2agent@ IUI., March, 2020.
5. R. P. Machera, "Teaching Intervention Strategies That Enhance Learning in Higher Education," Universal Journal of Educational Research, vol. 5, no. 5, pp. 733-743, 2017.
6. B. J. Casey, T. Cannonier, M. I. Conley, A. O. Cohen, D. M. Barch, M. M. Heitzeg, and A. M. Dale, "The adolescent brain cognitive development (ABCD) study: imaging acquisition across 21 sites," Developmental cognitive neuroscience, vol. 32, pp. 43-54, 2018.
7. J. O. Cooper, T. E. Heron, and W. L. Heward, "Applied behavior analysis (Vol. 2, pp. 37-46)," Upper Saddle River, NJ: Pearson/Merrill-Prentice Hall, 2007.
8. P. O. Towle, and P. A. Patrick, "Autism spectrum disorder screening instruments for very young children: a systematic review," Autism research and treatment, vol. 2016, no. 1, p. 4624829, 2016.
9. W. L. Heward, and C. L. Wood, "Exceptional children: An introduction to special education (p. 672)," Pearson Education/Merrill/Prentice Hall, 2006.
10. R. Kalra, K. Goyal, and M. Goyal, "Applied Behavioral Analysis (ABA): A Guide to Autism," In Rehabilitation Approach in Autism, 2025, pp. 135-144. doi: 10.1007/978-981-96-4162-8_8
11. L. Kanner, "Autistic disturbances of affective contact," Nervous child, vol. 2, no. 3, pp. 217-250, 1943.
12. G. Leisman, R. Alfasi, and R. Melillo, "Neurobiological and Behavioral Heterogeneity in Adolescents with Autism Spectrum Disorder," Brain Sciences, vol. 15, no. 10, p. 1057, 2025. doi: 10.3390/brainsci15101057
13. F. R. Volkmar, "Encyclopedia of autism spectrum disorders," Cham: Springer International Publishing, 2021.
14. C. A. Noggle, and A. S. Davis, "Advances in neuroimaging," In Understanding the biological basis of behavior: Developing evidence-based interventions for clinical, counseling and school psychologists, 2021, pp. 107-137. doi: 10.1007/978-3-030-59162-5_5
15. N. K. Logothetis, "What we can do and what we cannot do with fMRI," Nature, vol. 453, no. 7197, pp. 869-878, 2008. doi: 10.1038/nature06976
16. L. Licari, L. Nemer, and G. Tamburlini, "Children's health and environment: developing action plans," WHO Regional Office Europe, 2005.
17. X. N. Zong, and H. Li, "Growth and development of children in China: achievements, problems and prospects," World Journal of Pediatrics, vol. 20, no. 2, pp. 97-104, 2024.
18. R. A. Poldrack, and M. J. Farah, "Progress and challenges in probing the human brain," Nature, vol. 526, no. 7573, pp. 371-379, 2015. doi: 10.1038/nature15692
19. S. Suprihatin, and I. Tarjiah, "Evaluating the outcome of structured teaching intervention for children with autism," In 5th International Conference on Education and Technology (ICET 2019), December, 2019, pp. 286-289. doi: 10.2991/icet-19.2019.72
20. S. Nisar, and M. Haris, "Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder," Molecular psychiatry, vol. 28, no. 12, pp. 4995-5008, 2023. doi: 10.1038/s41380-023-02060-9
21. G. Vivanti, P. A. Fanning, D. R. Hocking, S. Sievers, and C. Dissanayake, "Social attention, joint attention and sustained attention in autism spectrum disorder and Williams syndrome: Convergences and divergences," Journal of autism and developmental disorders, vol. 47, no. 6, pp. 1866-1877, 2017.
22. C. Wong, S. L. Odom, K. A. Hume, A. W. Cox, A. Fettig, S. Kucharczyk, and T. R. Schultz, "Evidence-based practices for children, youth, and young adults with autism spectrum disorder: A comprehensive review," Journal of autism and developmental disorders, vol. 45, no. 7, pp. 1951-1966, 2015. doi: 10.1007/s10803-014-2351-z
23. A. C. Feng, J. Qiu, X. Chen, X. Liu, and X. N. Zuo, "Chinese color nest project (CCNP) I: Growing up in China," Chin. Sci. Bull., vol. 62, pp. 3008-3022, 2017.
24. J. Levman, P. MacDonald, A. R. Lim, C. Forgeron, and E. Takahashi, "A pediatric structural MRI analysis of healthy brain development from newborns to young adults," Human brain mapping, vol. 38, no. 12, pp. 5931-5942, 2017. doi: 10.1002/hbm.23799
25. Z. Chen, X. Wang, S. Zhang, and F. Han, "Neuroplasticity of children in autism spectrum disorder," Frontiers in psychiatry, vol. 15, p. 1362288, 2024. doi: 10.3389/fpsyt.2024.1362288
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