Pathogenetic and Therapeutic Insights of Depression
DOI:
https://doi.org/10.71222/f87e8g54Keywords:
depression, pathogenesis, treatment, diagnosisAbstract
Depression has become one of the major diseases that endanger public health and safety. With the march of society, people have become more aware of the dangers of depression, and scientists have made extensive research on depression. Now scientists have put forward some hypotheses recognized widely by the academic world about the pathogenesis of depression, while the exact pathogenesis of depression remains to be studied. Although some clinical treatments for depression have been explored, effective therapies to completely cure depression haven't been found. This thesis mainly concludes the progress of previous research on the symptoms, pathogenesis, diagnosis and treatments of depression, and gives a detailed and full introduction of depression. I hope that this paper can provide a multi-faceted knowledge for people who want to understand and do research on depression, and give a reference to future research on depression.
References
1. A. J. M. Loonen and S. A. Ivanova, "Circuits regulating pleasure and happiness — Mechanisms of depression," Front. Hum. Neurosci., vol. 10, p. 571, 2016, doi: 10.3389/fnhum.2016.00571.
2. J. Joormann and C. H. Stanton, "Examining emotion regulation in depression: A review and future directions," Behav. Res. Ther., vol. 86, pp. 35-49, 2016, doi: 10.1016/j.brat.2016.07.007.
3. F. F. Zhang et al., "Brain structure alterations in depression: Psychoradiological evidence," CNS Neurosci. Ther., vol. 24, no. 11, pp. 994-1003, 2018, doi: 10.1111/cns.12835.
4. W. Sun, E. Y. Lu, C. Wang, et al., "Neurobiological mechanisms for the antidepressant effects of mind-body and physical ex-ercises: A systematic review," Ment. Health Phys. Act., vol. 25, p. 100538, 2023, doi: 10.1016/j.mhpa.2023.100538.
5. K. Romer Thomsen et al., "Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain," Front. Behav. Neurosci., vol. 9, p. 49, 2015, doi: 10.3389/fnbeh.2015.00049.
6. M. T. Treadway and D. H. Zald, "Reconsidering anhedonia in depression: lessons from translational neuroscience," Neurosci. Biobehav. Rev., vol. 35, no. 3, pp. 537-555, 2011, doi: 10.1016/j.neubiorev.2010.06.006.
7. C. G. Beevers, "Editorial overview: The assessment, etiology, and treatment of unipolar depression," Curr. Opin. Psychol., vol. 4, pp. v-viii, Aug. 2015, doi: 10.1016/j.copsyc.2015.05.003.
8. W. Sargant, "Drugs in the treatment of depression," Br. Med. J., vol. 1, no. 5221, pp. 225-227, Jan. 1961, doi: 10.1136/bmj.1.5221.225.
9. TWCOTROCHAD and S. S. Hu, "Report on cardiovascular health and diseases in China 2021: an updated summary," J. Geriatr. Cardiol., vol. 20, no. 6, pp. 399-430, Jun. 2023, doi: 10.26599/1671-5411.2023.06.001.
10. S. Pal et al., "Retraction of Adsorption of cyanuric acid on activated carbon from aqueous solution: effect of carbon surface modification and thermodynamic characteristics," J. Colloid Interface Sci., vol. 314, no. 1, p. 347, 2007,doi: 10.1016/j.jcis.2006.07.027.
11. D. Liu, Y. Wang, Y. Xu, and K. Jiang, "Research progress in China on the assessment of cognitive function in schizophrenia," Shanghai Arch. Psychiatry, vol. 25, no. 5, pp. 266-275, Oct. 2013, doi: 10.3969/j.issn.1002-0829.2013.05.002.
12. H. L. Liu, J. Sun, S. F. Meng, and N. Sun, "Physiotherapy for patients with depression: Recent research progress," World J. Psy-chiatry, vol. 14, no. 5, pp. 635-643, May 2024, doi: 10.5498/wjp.v14.i5.635.
13. Fakhoury, M., "New insights into the neurobiological mechanisms of major depressive disorders," Gen. Hosp. Psychiatry, vol. 37, no. 2, pp. 172-177, 2015, doi: 10.1016/j.genhosppsych.2015.01.005.
14. C. A. Zarate, "A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression," Arch. Gen. Psychiatry, vol. 63, 2006, doi: 10.1001/archpsyc.63.8.856.
15. K. Mizoguchi et al., "Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission," Pharmacol. Biochem. Behav., vol. 91, no. 1, pp. 170-175, 2008, doi: 10.1016/j.pbb.2008.07.002.
16. N. Rasheed et al., "Differential response of central dopaminergic system in acute and chronic unpredictable stress models in rats," Neurochem. Res., vol. 35, no. 1, pp. 22-32, 2010, doi: 10.1007/s11064-009-0026-5.
17. H. Eyre and B. T. Baune, "Neuroimmunological effects of physical exercise in depression," Brain Behav. Immun., vol. 26, no. 2, pp. 251-266, 2012, doi: 10.1016/j.bbi.2011.09.015.
18. G. Perini, M. Cotta Ramusino, E. Sinforiani, S. Bernini, R. Petrachi, and A. Costa, "Cognitive impairment in depression: Recent advances and novel treatments," Neuropsychiatr. Dis. Treat., vol. 15, pp. 1249–1258, 2019, doi: 10.2147/NDT.S199746.
