Neuromodulation in Pain Management for Rehabilitation: Current Status and Future Perspectives
DOI:
https://doi.org/10.71222/pgpz5z94Keywords:
neuromodulation, pain management, rehabilitation, spinal cord stimulation, bioelectronic medicineAbstract
Neuromodulation techniques have gained significant attention in pain management, particularly in the rehabilitation of chronic pain conditions. These therapies target the nervous system to alter pain perception and promote recovery by modulating neural activity. This review provides an overview of the current state of neuromodulation in pain management, highlighting key techniques such as spinal cord stimulation, peripheral nerve stimulation, transcranial magnetic stimulation, and deep brain stimulation. We also explore the underlying neurophysiological mechanisms, clinical applications, and challenges associated with these therapies. The future of neuromodulation in rehabilitation is promising, with advancements in bioelectronic medicine and personalized, AI-driven approaches offering new opportunities for more effective and tailored treatments. However, challenges such as device accessibility, patient variability, and long-term efficacy need to be addressed to optimize their clinical use. This review concludes by discussing the potential directions for future research and the clinical implications for integrating neuromodulation into comprehensive pain management strategies.
References
1. L. Farinelli, M. Riccio, A. Gigante, and F. De Francesco, "Pain management strategies in osteoarthritis," Biomedicines, vol. 12, no. 4, p. 805, 2024. doi: 10.3390/biomedicines12040805.
2. S. N. El-Tallawy, J. V. Pergolizzi, I. Vasiliu-Feltes, et al., "Innovative applications of telemedicine and other digital health solu-tions in pain management: A literature review," Pain Ther., vol. 13, pp. 791-812, 2024. doi: 10.1007/s40122-024-00620-7.
3. H. Zakeri, P. Mahtosh, M. Radmehr, R. Rahbani, L. Montazeri, S. Moalemi, P. Mahdiyar, F. Hemati, and A. Karimi, "Pain management strategies in intensive care unit: Challenges and best practice," Galen Med. J., vol. 13, p. e3264, Apr. 29, 2024. doi: 10.31661/gmj.v12i.3264.
4. I. H. Cerda, A. Therond, S. Moreau, et al., "Telehealth and virtual reality technologies in chronic pain management: A narrative review," Curr. Pain Headache Rep., vol. 28, pp. 83-94, 2024. doi: 10.1007/s11916-023-01205-3.
5. J. E. Chelly, S. K. Goel, J. Kearns, O. Kopac, and S. Sadhasivam, "Nanotechnology for pain management," J. Clin. Med., vol. 13, no. 9, p. 2611, 2024. doi: 10.3390/jcm13092611.
6. R. Antel, S. Whitelaw, G. Gore, and P. Ingelmo, "Moving towards the use of artificial intelligence in pain management," Eur. J. Pain, vol. 29, no. 3, p. e4748, 2025. doi: 10.1002/ejp.4748.
7. P. Fusco, G. Pascarella, C. Stecco, et al., "Factors to consider for fascial plane blocks' success in acute and chronic pain man-agement," Minerva Anestesiol., vol. 90, no. 1-2, pp. 87-97, Jan.-Feb. 2024. doi: 10.23736/s0375-9393.23.17866-7.
8. J. A. Sturgeon, C. Cooley, and D. Minhas, "Practical approaches for clinicians in chronic pain management: Strategies and so-lutions," Best Pract. Res. Clin. Rheumatol., vol. 38, no. 1, p. 101934, 2024. doi: 10.1016/j.berh.2024.101934.
9. M. M. Rahman, Y. Y. Jo, Y. H. Kim, and C. K. Park, "Current insights and therapeutic strategies for targeting TRPV1 in neu-ropathic pain management," Life Sci., p. 122954, 2024. doi: 10.1016/j.lfs.2024.122954.
10. J. Nijs, O. Mairesse, and N. K. Tang, "The importance of sleep in the paradigm shift from a tissue-and disease-based pain management approach towards multimodal lifestyle interventions for chronic pain," Braz. J. Phys. Ther., vol. 28, no. 1, p. 100594, 2024. doi: 10.1016/j.bjpt.2024.100594.
11. C. Gong, H. Shan, Y. Sun, et al., "Social support as a key factor in chronic pain management programs: A scoping review," Curr. Psychol., vol. 43, pp. 25453-25467, 2024. doi: 10.1007/s12144-024-06233-9.
12. L. Weng, W. Lin, X. Lin, M. Liu, and J. Yang, "Randomized controlled trial of an app for cancer pain management," Support. Care Cancer, vol. 32, no. 4, p. 244, 2024. doi: 10.1007/s00520-024-08442-1.
